Sermorelin
The active core of human GHRH (1-29).
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For research and laboratory use only. Not for human or veterinary consumption.
About this compound
Sermorelin is the active N-terminal fragment of human growth-hormone-releasing hormone, comprising residues 1-29 — the shortest portion of native GHRH that retains full receptor activity. As a faithful representation of the body's own GHRH signal, it has long served as a classic comparator in GH and IGF-1 research.
By engaging the GHRH receptor on the pituitary, sermorelin supports the natural release of growth hormone in a physiologically patterned way. This authentic, rhythm-respecting mechanism is exactly what makes it such a valuable research benchmark.
Widely regarded as a reference standard for GHRH-driven studies, sermorelin is supplied as a stable lyophilized powder for laboratory and research use only.
Research overview
Native GHRH 1-29 fragment
Sermorelin reproduces residues 1-29 of human GHRH, the minimal sequence required to fully activate the GHRH receptor. Because it mirrors the body's own signaling molecule, it provides an authentic and well-understood mechanism for research. This fidelity is why it is so often chosen as a baseline GHRH peptide.
Natural GH-release support
Through GHRH-receptor engagement, sermorelin supports the pituitary's own pulsatile secretion of growth hormone. Research models favor it for studying GH release in a pattern that closely resembles native physiology. This makes it a useful tool for investigating the upstream control of the GH axis.
GH & IGF-1 comparator
Sermorelin is a long-standing comparator in studies of the GH-IGF-1 axis, where investigators benchmark newer analogs against the native fragment. Its established profile makes it a reliable reference point for characterizing GHRH-driven signaling. This comparator role keeps it central to growth-hormone research.
Aging & metabolic research
Because endogenous GHRH signaling is a focus in studies of metabolism and aging, sermorelin is frequently explored in these contexts within research models. It helps investigators examine how restoring a natural GHRH signal relates to metabolic and body-composition endpoints. These applications continue to drive interest in the peptide.
Research-grade quality
Sermorelin is supplied as a stable lyophilized powder intended strictly for laboratory and research use. It is prepared to a high representative purity standard appropriate for precise experimental work. It is not for human or veterinary use.
Prep it right
Reconstitute gently — add bacteriostatic water down the vial wall and swirl, don't shake. The lyophilized powder goes fully into solution without foaming.
Reconstituting? Work out concentration and draw volume in the reconstitution calculator.
Store the lyophilized vial at −20 °C, protected from light. Once reconstituted, refrigerate and use it within the diluent's window.
Lyophilization (freeze-drying) removes water under low pressure so the peptide sublimates from solid to vapor, leaving a stable powder that preserves its integrity until it is reconstituted with bacteriostatic water. Lyophilized vials are robust in transit and reach their longest shelf life when stored cold and protected from light.
All products are sold for laboratory and research use only and are not for human or veterinary consumption, diagnosis, or treatment of any kind. These statements have not been evaluated by the U.S. Food and Drug Administration. The products and statements are not intended to diagnose, treat, cure, or prevent any disease. Amino Meta is a chemical supplier and is not a compounding pharmacy or an outsourcing facility as defined under sections 503A and 503B of the Federal Food, Drug, and Cosmetic Act.
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