MOTS-c
Mitochondrial-derived metabolic peptide.
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For research and laboratory use only. Not for human or veterinary consumption.
About this compound
MOTS-c is a mitochondrial-derived peptide — a 16-residue signaling molecule encoded within mitochondrial DNA rather than the cell nucleus. This unique origin places MOTS-c at the heart of the conversation between mitochondria and the rest of the cell, making it one of the most compelling peptides in metabolic and cellular-energy research.
MOTS-c is prized for its connection to the AMPK pathway, the cell's master regulator of energy balance. By engaging this pathway, it is studied for its potential to support metabolic flexibility, insulin signaling, and efficient energy production at the cellular level.
Supplied as a stable lyophilized powder, MOTS-c gives investigators a well-defined tool for exploring mitochondrial signaling, metabolic health, and the biology of aged tissue. For laboratory and research use only.
Research overview
Mitochondrial signaling
As a mitochondrial-DNA-encoded peptide, MOTS-c sits at the center of mitochondrial-to-nuclear communication. Research explores how it relays metabolic signals from the mitochondria to coordinate the cell's energy response. This distinctive role makes it a uniquely valuable compound for studying the inner workings of cellular energy production.
AMPK pathway activation
MOTS-c is widely studied for its activation of the AMPK pathway, the central regulator of cellular energy homeostasis. By engaging AMPK, it is investigated for its potential to support energy balance, nutrient sensing, and metabolic adaptation. This mechanism underpins much of the research interest in MOTS-c as a metabolic signaling peptide.
Cellular energy metabolism
Research positions MOTS-c as a supporter of efficient cellular energy metabolism, helping cells use available fuel more effectively. Its influence on mitochondrial output makes it a focal point for studies on metabolic vitality and endurance in research models. Investigators view it as a key peptide for understanding how cells maintain energy under demand.
Insulin signaling & glucose handling
MOTS-c is studied for its role in insulin signaling and the way cells handle glucose. Research suggests it may help support insulin sensitivity and metabolic flexibility, particularly in models of metabolic stress. This makes it an important compound in the broader study of glucose metabolism and metabolic health.
Aged-tissue metabolic research
Because mitochondrial function tends to decline with age, MOTS-c is of particular interest in aged-tissue metabolic research. Studies examine its potential to support metabolic resilience and energy capacity in older biological models. This connection to healthy metabolic aging is one of the peptide's most actively investigated properties.
Prep it right
Reconstitute gently — add bacteriostatic water down the vial wall and swirl, don't shake. The lyophilized powder goes fully into solution without foaming.
Reconstituting? Work out concentration and draw volume in the reconstitution calculator.
Store the lyophilized vial at −20 °C, protected from light. Once reconstituted, refrigerate and use it within the diluent's window.
Lyophilization (freeze-drying) removes water under low pressure so the peptide sublimates from solid to vapor, leaving a stable powder that preserves its integrity until it is reconstituted with bacteriostatic water. Lyophilized vials are robust in transit and reach their longest shelf life when stored cold and protected from light.
All products are sold for laboratory and research use only and are not for human or veterinary consumption, diagnosis, or treatment of any kind. These statements have not been evaluated by the U.S. Food and Drug Administration. The products and statements are not intended to diagnose, treat, cure, or prevent any disease. Amino Meta is a chemical supplier and is not a compounding pharmacy or an outsourcing facility as defined under sections 503A and 503B of the Federal Food, Drug, and Cosmetic Act.
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