Selank
Tuftsin-analog stress-response peptide.
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For research and laboratory use only. Not for human or veterinary consumption.
About this compound
Selank is a synthetic heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences as a stable analog of the naturally occurring immunomodulatory peptide tuftsin. By extending tuftsin's short active fragment with a stabilizing sequence, Selank was engineered to remain intact far longer in research conditions while preserving the parent peptide's regulatory profile. It has become one of the most studied peptides in the Russian neuropeptide literature.
Selank is prized in research for its dual character: it sits at the crossroads of the nervous and immune systems, where it is investigated for its influence on stress-response circuitry, anxiety-related behavioral models, and the neurochemistry of calm, balanced arousal. Researchers are drawn to its reputation as an "anxiolytic without sedation" candidate — a peptide explored for promoting composure and steady focus rather than dampening it.
Supplied as a stable lyophilized powder for laboratory reconstitution, this listing is intended strictly for research use only (RUO) and is not for human or animal consumption.
Research overview
Tuftsin-derived stability
Selank's design starts from tuftsin, a short endogenous peptide with well-characterized immunoregulatory activity. By appending a stabilizing tail, researchers created an analog engineered to resist rapid breakdown and remain available for study far longer than the parent fragment. This stability is a major reason Selank is favored as a research tool for probing tuftsin-linked pathways under controlled conditions.
Stress-response & anxiety models
Selank is best known in research for its behavioral profile in anxiety-related models, where it is studied as an anxiolytic-leaning candidate. Investigators are particularly interested in its reported ability to support a calm, regulated stress response without the sedation typically associated with classical anxiolytics. This positions Selank as a compelling subject for work exploring resilience to acute and chronic stressors.
GABA & monoamine neurochemistry
Mechanistic research has linked Selank to modulation of GABAergic signaling and to changes in monoamine neurotransmitter systems, including serotonin and dopamine pathways. These interactions are thought to underlie its balanced influence on mood and arousal in study models. The peptide's effect on this neurochemical network makes it a frequent focus of investigations into emotional regulation and equilibrium.
Cognition & focus
Beyond its calming profile, Selank is explored for its supportive effects on attention, mental clarity, and cognitive performance under stress in research settings. The combination of reduced anxiety-like behavior alongside maintained or enhanced focus is a recurring theme in the literature. This dual quality drives interest in Selank as a candidate for studying composed, sustained cognitive function.
Immune-system crosstalk
As a tuftsin analog, Selank retains an immunomodulatory dimension that distinguishes it from purely neuroactive peptides. Research examines how its influence on immune signaling may intersect with its neurochemical effects, reflecting the deep links between stress, immunity, and brain function. This neuro-immune crosstalk is one of the most intriguing aspects of Selank as a research compound.
Prep it right
Reconstitute gently — add bacteriostatic water down the vial wall and swirl, don't shake. The lyophilized powder goes fully into solution without foaming.
Reconstituting? Work out concentration and draw volume in the reconstitution calculator.
Store the lyophilized vial at −20 °C, protected from light. Once reconstituted, refrigerate and use it within the diluent's window.
Lyophilization (freeze-drying) removes water under low pressure so the peptide sublimates from solid to vapor, leaving a stable powder that preserves its integrity until it is reconstituted with bacteriostatic water. Lyophilized vials are robust in transit and reach their longest shelf life when stored cold and protected from light.
All products are sold for laboratory and research use only and are not for human or veterinary consumption, diagnosis, or treatment of any kind. These statements have not been evaluated by the U.S. Food and Drug Administration. The products and statements are not intended to diagnose, treat, cure, or prevent any disease. Amino Meta is a chemical supplier and is not a compounding pharmacy or an outsourcing facility as defined under sections 503A and 503B of the Federal Food, Drug, and Cosmetic Act.
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